Five-year Surveillance of Antimicrobial Resistance Changes and Epidemiological Characteristics in Pseudomonas aeruginosa: A Retrospective Study in a Chinese City Hospital

Background: In recent years, the widespread use of antibiotics has resulted in increased rates antibiotic resistance (ABR). Pseudomonas aeruginosa is one most important opportunistic pathogens causing hospital-acquired infections. continuously to commonly used clinical antimicrobial drugs, bringing great difficulties treatment. Objectives: This retrospective study investigated epidemiological characteristics P. and changes ABR over a 5-year period at hospital Shandong Province, China. Methods: strains were collected from 2015 2019. The susceptibility testing employed Kirby-Bauer disk diffusion method broth microdilution (VITEK-2 compact system), according guidelines by Clinical Laboratory Standards Institute. Data analyzed using WHONET 5.6 SPSS V. 21.0 software. Results: A total 3,324 isolated specimens (604, 631, 700, 595, 794 2019, respectively). highest detection respiratory tract (72.54%). was seen aztreonam, followed ciprofloxacin, levofloxacin, imipenem. isolation for carbapenem-resistant (CRPA) multidrug-resistant (MDRPA) ranged 15.21 - 18.38% 17.31 27.31%, respectively. Also, extensively drug-resistant (XDRPA) 1.86 3.52%. Conclusions: main sources isolates older adult patients with chronic diseases. CRPA, MDRPA, XDRPA decreased period. However, drug situation remains serious concern. Hence, continued infection control stewardship basic research on bacterial are essential.